| Medicine | |
| Alchohol Interaction | Taking metformin with alcohol can cause lactic acidosis and you may experience malaise, respiratory distress, slow or irregular heartbeat, sleepiness, stomach upset, or other unusual symptoms. |
| Pregnancy Interaction | Gzide Total 30 Tablet SR may be unsafe to use during pregnancy.Animal studies have shown adverse effects on the foetus, however, there are limited human studies. The benefits from use in pregnant women may be acceptable despite the risk. Please consult your doctor. |
| Lactation Interaction | Gzide Total 30 Tablet SR is probably safe to use during lactation. \nLimited human data suggests that the drug does not represent a significant risk to the baby. |
| Common Side Effect | Hypoglycemia (low blood sugar level), Nausea, Altered taste, Diarrhoea, Stomach pain, Headache, Edema (swelling), Weight gain, Blurred vision, Bone fracture, Respiratory tract infection. |
| How to Use | Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Gzide Total 30 Tablet SR is to be taken with food. Gzide Total 30 Tablet SR may cause stomach upset if taken on empty stomach. |
| Driving | Your ability to drive may be affected if your blood sugar is low or high. If this happens, do not drive. |
| Kidney | Gzide Total 30 Tablet SR should be used with caution in patients with kidney disease. Dose adjustment of Gzide Total 30 Tablet SR may be needed. Please consult your doctor.Use of Gzide Total 30 Tablet SR is, however, not recommended in patients with severe kidney disease. Regular monitoring of kidney function test is advisable while you are taking this medicine. |
| Liver | Gzide Total 30 Tablet SR should be used with caution in patients with liver disease. Dose adjustment of Gzide Total 30 Tablet SR may be needed. Please consult your doctor.Gzide Total 30 Tablet SR is generally started with low dose in patients with mild to moderate liver disease and its use is not recommended in patients with severe liver disease. |
| Mechanism of action | Gzide Total 30 Tablet SR is a combination of three antidiabetic medicines: Gliclazide, Pioglitazone and Metformin. tThey work by different mechanisms to provide better control of blood sugar when single or dual therapy is not effective. Gliclazide is a sulfonylurea which works by increasing the amount of insulin released by the pancreas in order to lower the blood glucose. Pioglitazone is a thiazolidinedione which increases insulin sensitivity. Metformin is a biguanide. It works by lowering glucose production in the liver, delaying glucose absorption from intestines and further increasing the body's sensitivity to insulin. |
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