| Medicine | |
| Alchohol Interaction | Taking pioglitazone with alcohol may affect blood glucose levels in patients with diabetes. |
| Pregnancy Interaction | Pionorm gm 5 mg/500 mg/15 mg Tablet may be unsafe to use during pregnancy.Animal studies have shown adverse effects on the foetus, however, there are limited human studies. The benefits from use in pregnant women may be acceptable despite the risk. Please consult your doctor. |
| Lactation Interaction | Pionorm gm 5 mg/500 mg/15 mg Tablet is probably safe to use during lactation. \nLimited human data suggests that the drug does not represent a significant risk to the baby.Monitor the breastfed baby’s blood sugar during treatment with Pionorm gm 5 mg/500 mg/15 mg Tablet |
| Common Side Effect | Hypoglycemia (low blood sugar level), Altered taste, Nausea, Diarrhoea, Stomach pain, Headache, Edema (swelling), Weight gain, Bone fracture, Blurred vision, Respiratory tract infection. |
| How to Use | Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Pionorm gm 5 mg/500 mg/15 mg Tablet is to be taken with food.Pionorm gm 5 mg/500 mg/15 mg Tablet may cause stomach upset if taken empty stomach. |
| Driving | Your ability to drive may be affected if your blood sugar is low or high. If this happens, do not drive. |
| Kidney | Pionorm gm 5 mg/500 mg/15 mg Tablet is probably unsafe to use in patients with kidney disease and should be avoided. Please consult your doctor. |
| Liver | Pionorm gm 5 mg/500 mg/15 mg Tablet should be used with caution in patients with liver disease. Dose adjustment of Pionorm gm 5 mg/500 mg/15 mg Tablet may be needed. Please consult your doctor.Use of Pionorm gm 5 mg/500 mg/15 mg Tablet is not recommended in patients with severe liver disease. |
| Mechanism of action | Pionorm gm 5 mg/500 mg/15 mg Tablet is a combination of three antidiabetic medicines: Glibenclamide, Metformin and Pioglitazone. tThey work by different mechanisms to provide better control of blood sugar when single or dual therapy is not effective. Glibenclamide is a sulfonylurea which works by increasing the amount of insulin released by the pancreas in order to lower the blood glucose. Metformin is a biguanide. It works by lowering glucose production in the liver, delaying glucose absorption from intestines and increasing the body's sensitivity to insulin. Pioglitazone is a thiazolidinedione which further increases insulin sensitivity. |